What is Neonorm™ Foal and how does it compare to other equine anti-diarrheal products?
Neonorm™ Foal is a non-prescription product for foals that contains a standardized botanical extract from the Croton lechleri tree. The product is formulated as a peppermint-flavored paste and comes in 30 mL syringes. It is a clinically tested, first-in-class product.
Viruses, toxins, and/or bacteria trigger a reaction in the gut lining cells, causing chloride channels in these cells to open. As chloride flows into the lumen of the gut through these channels, water naturally follows via osmosis. This results in excess fluid in the lumen and, consequently, in watery feces. Neonorm™ Foal works by regulating these chloride channels, essentially normalizing fluid exchange between the gut lining cells and the lumen of the gut.
Where does Neonorm™ Foal come from?
The standardized botanical extract in Neonorm™ Foal is isolated and purified from the Amazonian tree species Croton lechleri, which has a rich history of use by indigenous people of the Western Amazon rainforest of South America. Local and indigenous people in this region commonly take small quantities of this latex orally when experiencing diarrhea, stomach ulcers, coughs and flu.
What are the ingredients in Neonorm™ Foal?
The core ingredient in Neonorm™ Foal is a standardized botanical extract derived from the Croton lechleri tree.
How does Neonorm™ Foal work?
Neonorm™ Foal is a first-in-class product that functions at the cellular level by normalizing the flow of chloride ions into the gut lumen from epithelial cells lining the intestine. The flow of chloride ions causes water to follow via osmosis into the gut lumen, resulting in secretory diarrhea.
Since Neonorm™ Foal works to normalize chloride ion channels, does it block the uptake of other nutrients from within the gut?
No. Neonorm™ Foal’s mechanism of action is specific to the CFTR (cystic fibrosis transmembrane conductance regulator) and CaCC (calcium-activated chloride channels) channels on the side of the epithelial cells facing the lumen. It partially closes, but does not completely block, those gates that allow the secretion of chloride into the lumen in response to a pathological stimulant (the presence of E. coli toxins, for instance). The secretion of water along with chloride ions is a consequence of this process.
Nutrient absorption does not occur through chloride channels, therefore Neonorm™ Foal does not affect nutrient absorption; it helps maintain a normal physiological state and does not affect gut motility (i.e. it does not cause constipation).
What is the recommended regimen for use?
Give 10 mL of Neonorm™ Foal 2-3 times daily for up to three days. A full regimen is 2-3 30 mL syringes.
How do I administer Neonorm™ Foal?
Neonorm™ Foal comes in an easily-administered, peppermint-flavored paste that is given orally.
For best results, when should I give Neonorm™ Foal?
Neonorm™ Foal should be given as soon as loose stool appears, or as soon as the foal becomes listless or quits nursing. It can also be administered to foals that are believed to be at risk for developing diarrhea.
When do you give Neonorm™ Foal relative to feeding?
The paste can be given before or right after feeding.
Does giving Neonorm™ Foal affect the foal’s appetite?
Typically, the foal will feel better and the appetite will improve.
Can you give Neonorm™ Foal in conjunction with other medications and treatments?
Yes. Neonorm™ Foal can be given with probiotics, oral electrolytes and other medications and treatments; there are no known contraindications. There are no known interactions with other non-prescription products, feed additives or antibiotics. The product has been successfully administered at the same time as oral probiotics.
Is Neonorm™ Foal an antibiotic?
No. Neonorm™ Foal is not an antibiotic. It does not work to treat the infection causing diarrhea and is not meant to replace or substitute for normal standard of care.
Can Neonorm™ Foal be given to a foal of any age?
Yes. Neonorm™ Foal can be given to any age foal. Colostrum administration is always recommended prior to giving Neonorm™ Foal.
Does Neonorm™ Foal cause constipation?
No. Neonorm™ Foal does not cause constipation. Neonorm™ Foal acts to normalize fluid exchange without stopping it completely; therefore, constipation is not an issue, even at high doses.
Can I overdose a foal on Neonorm™ Foal?
No. Laboratory animals have been given Neonorm™ at doses up to 400 times the effective dose without serious, adverse effects; therefore, overdose it not a cause for concern.
How long does it take Neonorm™ Foal to work?
Effects have been observed within 24 hours of beginning the regimen.
Is there anything special I should look for after giving Neonorm™ Foal?
You should observe normal stool formation and a general improvement in the health of the foal. If the foal appears dehydrated it should be seen by a veterinarian immediately.
Are there any safety concerns with Neonorm™ Foal?
No. Neonorm™ Foal is safe to use in foals of all ages. The product is not absorbed systemically and acts locally in the gut only. Safety studies in various species of animals confirm this.
Are there any side effects?
No. No side-effects have been noted.
Is there a withdrawal period?
No. There is no withdrawal period since Neonorm™ Foal is not absorbed or metabolized by the body.
If my foal often experiences bouts of diarrhea, how frequently can I give Neonorm™ Foal?
As Neonorm™ Foal is not absorbed systemically, continuous administration is safe, if needed. However, if your foal is experiencing regular bouts of diarrhea a veterinarian should be consulted.
What if I forget to give my foal a Neonorm™ Foal dose one day?
Continue dosing until the foal receives the recommended regimen.
Is it safe to use Neonorm™ Foal in nursing foals?
Yes. Neonorm™ Foal is safe to use in nursing foals. Data from safety and efficacy studies performed in 2015 show no adverse effects in over 80 nursing foals as young as 12 hours of age. Nevertheless, it is always recommended that foals receive an adequate amount of colostrum before receiving any other product or medication.
Is Neonorm™ Foal safe and effective to use in adult horses? Pregnant mares? Miniature horses?
The safety and efficacy of Neonorm™ Foal has not been evaluated in adult horses, pregnant mares or miniature horses. However, extensive safety studies have been performed in multiple species, including humans, and as the product is not absorbed systemically, adverse effects in adults, pregnant mares and/or the developing fetus and miniature horses are not expected. Additionally, there are anecdotal reports for the successful, safe use in adult horses. Nevertheless, consult your veterinarian before using Neonorm™ Foal in adult horses, pregnant mares or miniature horses.