Neonorm Calf

$59.00$399.00

Veterinarians: See below for veterinary purchase channels.

An Advanced New Product That Inhibits Fluid Loss at the Cellular Level

A Clinically Proven Solution
It’s time to rethink the management of fluid retention in dairy and beef calves.
Available in 30, 60 and 240-count bottles.

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Avoid Dehydration

Neonorm Calf is an advanced new product that helps dairies and beef farms proactively retain fluid in calves.

Figure 2: Adapted from Wattiaux, M. A. Heifer raising – birth to weaning. Neonatal diarrhea. Babcock Institute for International Dairy Research and Development. 2005. University of Wisconsin-Madison.

The Problem

Dehydration from scours, diarrhea, or other digestive problems poses a significant threat to the health and future productivity of newborn dairy and beef calves, and significantly increases the expenses and labor required to care for the animals. Current products cannot help calves retain fluids quickly enough to avoid severe dehydration—the ultimate goal in managing scours.

The Solution

Neonorm Calf helps dairies and beef farms proactively retain fluid in calves—helping the animals avoid debilitating, dangerous levels of dehydration. Calves that avoid severe dehydration before it occurs are better equipped to fight off the infection that led to scours. Neonorm Calf is an advanced product that operates at the cellular level to inhibit the flow of fluids into the intestines—the location where vital fluids leave the body during scours. It is not an electrolyte or a nutritional supplement.

A Clinically Proven Solution

A study evaluating the effect of Neonorm Calf on diarrhea in newborn calves was published in Journal of Dairy Science, the official, peer-reviewed journal of the American Dairy Science Association, in 2015. The study was conducted by researchers from Cornell University College of Veterinary Medicine. The study results suggest that Neonorm Calf can significantly increase the fecal dry matter of neonatal calves with experimentally-induced enterotoxigenic E. coli diarrhea. Higher fecal dry matter is an indication of less water loss and lower dehydration risk.

Figure 1: Schematic of Neonorm Calf Inhibition of fluid loss

Now OMRI Listed® for Organic Use!

The Organic Materials Review Institute (OMRI) has reviewed Neonorm Calf and determined that it is allowed for use in compliance with the U.S. Department of Agriculture National Organic Program. OMRI is an international nonprofit organization that determines which input products are allowed for use in organic production and processing.

With concern mounting in the U.S. about antimicrobial resistance in humans, there is growing interest in new products and techniques to better manage the serious consequences of calf dehydration. Neonorm Calf is a clinically-tested, non-antibiotic tool for any operation—organic or non-organic—looking to improve scours management.

It’s Time to Rethink the Management of Fluid Retention in Calves

Remember, it is dehydration (fluid loss from the circulatory system of the animal into the lumen of the gut) that places preweaned calves at risk of decreased lifetime productivity and death. With concern mounting in the U.S. about antimicrobial resistance in humans, there is growing interest in new products and techniques to better manage the serious consequences of dehydration in calves.

As a fluid retention agent, often used in conjunction with practices such as fluid replacement, Neonorm Calf is providing dairies and calf farms across the country with immediate benefits and greater control over the scours management process.

A Natural Product That is Easy to Administer

Neonorm Calf is a natural product that contains a standardized botanical extract derived from the Croton lechleri tree, which is sustainably harvested. The product acts locally in the gut and is minimally absorbed systemically.

Neonorm Calf is an enteric-coated bolus designed to be given orally to preweaned dairy calves once every 12 hours, as needed, for up to three days.

Dosage

Enteric-coated bolus is designed to be given orally to preweaned dairy and beef calves once every 12 hours, as needed, for up to three days. Compatible with electrolytes and other standards of care. Small bolus formulation allows for easy delivery by hand or balling gun.

This product cannot be shipped outside the U.S. 

Refund & Return Policy: Please note that all sales are final.

Neonorm Calf’s Ethnobotanical Origins

By Steven R. King, Ph.D.

The term ethnobotanical refers to the use of plants by indigenous people in the course of their everyday lives, including the use of plants for medicine.

The product, Neonorm Calf, and the standardized botanical extract it contains result from decades of research that began with the expertise of traditional healers of the Amazon rainforest.

Jaguar CEO Lisa Conte with a Blue Grey cow at the Clayton Family Farm in Devon, UK

The standardized botanical extract in Neonorm Calf is derived from the Amazonian tree species, Croton lechleri, and has a rich history of medicinal use by indigenous peoples in the Western Amazon rainforests of South America. The tree produces a blood red latex from which the standardized botanical exact Neonorm is isolated and purified. The tree is commonly called “Sangre de drago” in Spanish which translates to “Dragon’s blood” in English. 

This Croton lechleri tree is one of the most widely used plant-derived medicines in the western hemisphere. Red latex from Croton lechleri trees continues to be part of rural and urban traditional medicine in multiple countries including Peru, Ecuador and Bolivia.

Indigenous people utilize the red latex to treat a variety of medical conditions. It’s most common uses are taking small quantities of the latex orally to treat diarrhea, stomach ulcers, coughs and flu. The red latex is also applied topically as a wound healing agent for cuts, open sores and for healing the gums after tooth extractions. It has been and continues to be used to treat humans as well as dogs and livestock.

Because of its widespread medicinal use, there has been extensive research conducted on the chemistry and pharmacology of this red latex. The product, Neonorm Calf, and the standardized botanical extract it contains are the result of decades of research that began with the expertise of traditional healers of the Amazon rainforest.

Neonorm Calf is extracted and purified from the red latex of Croton lechleri, shown here as it exudes from the cut bark of the tree.

The Croton lechleri tree is rapidly growing and abundant in multiple countries. Jaguar Animal Health and its predecessor companies always focus on the long-term sustainable management of the tree as part of our commitment to helping local communities both conserve their natural resources while also earning income for the basic needs of their families, such as food, clothing, health care and education. Jaguar Animal Health employees have been collaborating with local communities, business partners and scientists for the past 25 years to make certain that the development and sale of this product provides benefit to local communities. Large numbers of these trees have been planted, and re-planted upon harvesting, across Peru in collaboration with communities and small local businesses.

More Blue Grey cows at the Clayton Family Farm in Devon, UK

What is Neonorm™ Calf?

Neonorm™ Calf is a non-prescription product for neonatal dairy and beef calves (<2 weeks old) containing a standardized botanical extract from the Croton lechleri tree. The product is formulated as a 1.3 gram enteric-coated bolus designed to help dairies and beef farms proactively retain fluid in calves—helping the animals avoid debilitating, dangerous levels of dehydration.

Neonorm™ Calf should be used at the first sign of diarrhea and dehydration associated with scours and is not intended to replace or substitute for normal standard of care (i.e., use of electrolytes). The economic benefits derived from using Neonorm™ Calf include reduced expenses for both care and labor, heavier weaning weights and earlier weaning. Results from a study conducted at Cornell University (Ithaca, NY) determined that the total economic benefit from health endpoints, such as weight gain, from Neonorm™ Calf could be as much as $110 per calf. Economic Benefits Calculator

Where does Neonorm™ Calf come from?

The standardized botanical extract in Neonorm™ Calf is isolated and purified from the Amazonian tree species Croton lechleri, which has a rich history of medicinal use by indigenous people of the Western Amazon rainforest of South America. Local and indigenous people in this region use the red latex from this tree to treat a variety of medical conditions, commonly taking small quantities of this latex orally to treat diarrhea, stomach ulcers, coughs and flu.

What are the ingredients in Neonorm™ Calf?

The active ingredient in Neonorm™ Calf is SB-300, which comes from the Croton lechleri tree. In addition, it contains the following in-active excipients: Microcrystalline cellulose, Magnesium stearate, Hydroxypropyl methylcellulose, Triethyl citrate, Eudragit L30D55 (methacrylic acid copolymer), PlasACRYL HTP20 (glycerol monostearate emulsion), and Titanium dioxide.

How does Neonorm™ Calf work?

Neonorm™ Calf is a first-in-class product that functions at the cellular level by normalizing the flow of chloride ions into the gut lumen from epithelial cells lining the intestine. The flow of chloride ions causes water to follow via osmosis into the gut lumen, resulting in secretory diarrhea.

Since Neonorm™ Calf works to normalize chloride ion channels, does it block the uptake of other nutrients from within the gut?

No. Neonorm™ Calf’s mechanism of action is specific to the CFTR (cystic fibrosis transmembrane conductance regulator) and CaCC (calcium-activated chloride channels) channels on the side of the epithelial cells facing the lumen. It partially closes, but does not completely block, those channels that allow the secretion of chloride into the lumen in response to a pathological stimulant (the presence of E. coli toxins, for instance). The secretion of water along with chloride ions is a consequence of this process.

Nutrient absorption does not occur through chloride channels, therefore Neonorm™ Calf does not affect nutrient absorption; it helps maintain a normal physiological state and does not affect gut motility (i.e. it does not cause constipation).

In two clinical studies done at Cornell University, dairy calves in the treatment group showed a positive average daily weight gain over the first 10 days when compared to placebo-treated calves.

What is the recommended regimen for use?

Neonorm™ Calf should be given orally to preweaned calves once every 12 hours, as needed, for up to three days (up to 6 boluses per calf).

How do I administer Neonorm™ Calf?

Neonorm™ Calf is an enteric-coated bolus that can be administered by hand or using a balling gun. DO NOT BREAK THE BOLUS, as this will damage the enteric coating, which protects the active botanical extract from stomach acid damage and enables the active extract to go to work in the intestines.

When do you give Neonorm™ Calf relative to feeding?

The bolus can be given before or right after feeding.

Can you give Neonorm™ Calf in conjunction with other medications and treatments?

Yes. Neonorm™ Calf can be given with probiotics, oral electrolytes and other medications and treatments; there are no known contraindications. There are no known interactions with other non-prescription products, feed additives or antibiotics. The product has been successfully administered at the same time as oral electrolytes. Neonorm™ Calf should be given as soon as loose stool appears, or as soon as the calf becomes listless or quits nursing.

Is Neonorm™ Calf an antibiotic?

No. Neonorm™ Calf is not an antibiotic. It does not work to treat the infection causing diarrhea or scours and is not meant to replace or substitute for normal standard of care.

Is Neonorm™ Calf similar to psyllium?

No. Psyllium is a fermentable fiber, gel-forming, non-starch polysaccharide that slows a calf’s gastrointestinal motility and reduce nutrient absorption. Calves suffering from secretory diarrhea will not benefit from psyllium.

Can Neonorm™ Calf be used in conjunction with pasteurized milk?

Yes. Typically, calves are fed whole milk, pasteurized, non-saleable milk, or milk replacer. Neonorm™ Calf can be administered to diarrheic calves regardless of the choice of liquid feed.

Does Neonorm™ Calf cause constipation?

No. Neonorm™ Calf does not cause constipation. Neonorm™ Calf acts to normalize fluid exchange without stopping it completely; therefore, constipation is not an issue, even at high doses.

Can I overdose a calf on Neonorm™ Calf?

No. Laboratory animals have been given Neonorm™ at doses up to 400 times the effective dose without serious, adverse effects; therefore, overdose it not a cause for concern.

How do I know when my calf needs Neonorm™ Calf?

Any calf less than 15 days of age with loose stool can benefit from Neonorm™ Calf.

Can Neonorm™ Calf be given to a calf of any age?

Yes. Neonorm™ Calf can be given to any age calf.

When is the use of Neonorm™ Calf recommended?

Neonorm™ Calf should be given to pre-weaned dairy or beef calves at the first sign of diarrhea and dehydration associated with scours or given to healthy calves that the producer considers to be at risk for developing diarrhea.

How long does it take Neonorm™ Calf to work?

Effects have been observed within 24 hours of beginning the regimen.

Is there anything special I should look for after giving Neonorm™ Calf?

You should observe normal stool formation and a general improvement in the health of the calf. If the calf is dehydrated, it should be given fluid as soon as possible. If the problem persists, contact your veterinarian.

What else can I do for my calf?

The standard of care for combating dehydration associated with scours is to give calves oral electrolytes, which are entirely compatible with Neonorm™ Calf. For further advice, please consult your veterinarian.

Are there any safety concerns with Neonorm™ Calf?

No. Neonorm™ Calf is safe to use in calves of all ages. The product is not absorbed systemically and acts locally in the gut only. Safety studies in various species of animals confirm this. Also, a comparable, FDA-approved prescription product is available on the human health market.

Are there any side effects?

No. No side-effects have been noted.

Should I give Neonorm™ Calf to all my calves?

There is no risk in giving Neonorm™ Calf to all your calves. Results from a clinical study done at Cornell University (Ithaca, NY) showed significantly fewer events of naturally occurring diarrhea as a result of prophylactic use of the standardized botanical extract in Neonorm™ Calf.

Is there a withdrawal period?

No. There is no withdrawal period since Neonorm™ Calf is not absorbed or metabolized by the body.

If my calf often experiences bouts of diarrhea, how frequently can I give Neonorm™ Calf?

As Neonorm™ Calf is not absorbed systemically, continuous administration is safe, if needed. Please consult your veterinarian with any further questions.

What if I forget to give my calf a Neonorm™ Calf dose one day?

Continue dosing until symptoms improve or the calf receives the recommended 6-bolus regimen.

Is it safe to use in adult cattle? Heifers? What is the recommended dose?

The safety of Neonorm™ Calf has not been evaluated in adult cattle or heifers. Please consult your veterinarian before giving Neonorm™ Calf to adult cattle or heifers.

Is it safe to use in nursing calves?

Yes, Neonorm™ Calf is safe to use in nursing calves.

Can I use Neonorm™ Calf on my beef calves as well as my dairy calves?

Yes. Neonorm™ Calf can be given to beef calves as well as dairy calves. Nevertheless, please consult your veterinarian.

Can I use Neonorm™ Calf on all calf diarrhea cases, no matter the cause?

Neonorm™ Calf is safe to use and will likely be effective in calves with diarrhea, no matter the cause.

Is there any equivalent to Neonorm™ Calf on the market?

No. Neonorm™ Calf contains a first-in-class standardized botanical extract specifically formulated to reduce fluid loss and promote normal stool formation.

Is Neonorm™ Calf superior to other “gut health” products?

Neonorm™ Calf is the latest advancement in neonatal calf care to help inhibit fluid loss. It is the first in a new class of anti-secretory products that work locally in the gut, and it is not absorbed by the body. To our knowledge, there is nothing else like it on the market today.

Can Neonorm™ Calf be used on organic dairy and beef farms?

Yes. The Organic Materials Review Institute (OMRI) has reviewed Neonorm™ Calf and determined that it is allowed for use in compliance with the U.S. Department of Agriculture National Organic Program. OMRI is an international nonprofit organization that determines which input products are allowed for use in organic production and processing.

With concern mounting in the U.S. about antimicrobial resistance in humans, there is growing interest in new products and techniques to better manage the serious consequences of calf dehydration. Neonorm Calf is a clinically-tested, non-antibiotic tool for any operation—organic or non-organic—looking to improve scours management.

Dairy producers can order Neonorm Calf through these distributors:

Veterinarians can order Neonorm Calf through these distributors:

3 reviews for Neonorm Calf

  1. Chelsea Lavoie, Metcalf Farm

    We’ve used Neonorm Calf on close to 100 calves and it is working really well.

  2. Jennifer Brooks, Brooks Family Farms

    I absolutely love Neonorm. I’ve been using it for a couple years now and have seen such a difference in treated calves! Great product! Thank you!

  3. Kathie Arnold, Twin Oaks Dairy, Truxton, NY

    Neonorm™ Calf gives us another welcome tool in the toolbox for our certified organic calves.

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